Relationship between GNAS1 T393C polymorphism and aseptic loosening after total hip arthroplasty.

ABSTRACT:

Background

Aseptic loosening is a main cause for revision surgery after total hip arthroplasty (THA) and there is no reliable marker for the early detection of patients at high risk. This study has been performed to validate association of the T393C polymorphism (rs7121) in the GNAS1 gene, encoding for the alpha-subunit of heterotrimeric G-protein Gs, with risk for and time to aseptic loosening after THA, which has been demonstrated in our previous study.

Methods

231 patients with primary THA and 234 patients suffering from aseptic loosening were genotyped for dependency on GNAS1 genotypes and analyzed.

Results

Genotyping revealed almost similar minor allele frequencies of 0.49 and 0.46, respectively. Consistently, genotype distributions of both groups were not signif

SUBMITTER: Stelmach P 

PROVIDER: S-EPMC5568317 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature