Distinct aging profiles of CD8+ T cells in blood versus gastrointestinal mucosal compartments.

ABSTRACT: A hallmark of human immunosenescence is the accumulation of late-differentiated memory CD8+ T cells with features of replicative senescence, such as inability to proliferate, absence of CD28 expression, shortened telomeres, loss of telomerase activity, enhanced activation, and increased secretion of inflammatory cytokines. Importantly, oligoclonal expansions of these cells are associated with increased morbidity and mortality risk in elderly humans. Currently, most information on the adaptive immune system is derived from studies using peripheral blood, which contains approximately only 2% of total body lymphocytes. However, most lymphocytes reside in tissues. It is not clear how representative blood changes are of the total immune status. This is especially relevant with regard to the hum

SUBMITTER: Dock J 

PROVIDER: S-EPMC5568404 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature