Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2.

ABSTRACT: Complement plays an important role in the pathogenesis of rheumatoid arthritis. Although the alternative pathway (AP) is known to play a key pathogenic role in models of rheumatoid arthritis, the importance of the lectin pathway (LP) pattern recognition molecules such as ficolin (FCN) A, FCN B, and collectin (CL)-11, as well as the activating enzyme mannose-binding lectin-associated serine protease-2 (MASP-2), are less well understood. We show in this article that FCN A^-/- and CL-11^-/- mice are fully susceptible to collagen Ab-induced arthritis (CAIA). In contrast, FCN B^-/- and MASP-2^-/-/sMAp^-/- mice are substantially protected, with clinical disease activity decreased significantly (p < 0.05) by 47 a

SUBMITTER: Banda NK 

PROVIDER: S-EPMC5568486 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature