Real-time multislice MRI during continuous positive airway pressure reveals upper airway response to pressure change.

ABSTRACT:

Purpose

To determine if a real-time magnetic resonance imaging (RT-MRI) method during continuous positive airway pressure (CPAP) can be used to measure neuromuscular reflex and/or passive collapsibility of the upper airway in individual obstructive sleep apnea (OSA) subjects.

Materials and methods

We conducted experiments on four adolescents with OSA and three healthy controls, during natural sleep and during wakefulness. Data were acquired on a clinical 3T scanner using simultaneous multislice (SMS) RT-MRI during CPAP. CPAP pressure level was alternated between therapeutic and subtherapeutic levels. Segmented airway area changes in response to rapid CPAP pressure drop and restoration were used to estimate 1) upper airway loop gain (UALG), and 2) anatomical risk factors, inc

SUBMITTER: Chen W 

PROVIDER: S-EPMC5568520 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature