Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: a systematic meta-analysis.

ABSTRACT:

Objective

Genome-wide association studies have identified many obesity/body mass index (BMI)-associated loci in Europeans and East Asians. Since then, a large number of studies have investigated the role of BMI-associated loci in the development of type 2 diabetes (T2D). However, the results have been inconsistent. The objective of this study was to investigate the associations of eleven obesity/BMI loci with T2D risk and explore how BMI influences this risk.

Methods

We retrieved published literature from PubMed and Embase. The pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated using fixed- or random-effect models.

Results

In the meta-analysis of 42 studies for 11 obesity/BMI-associated loci, we observed a statistically significant association

SUBMITTER: Xi B 

PROVIDER: S-EPMC5568704 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature