Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models.

ABSTRACT: Pulmonary fibrosis is scarring of the lungs that can arise from radiation injury, drug toxicity, environmental or genetic causes, and for unknown reasons [idiopathic pulmonary fibrosis (IPF)]. Overexpression of collagen is a hallmark of organ fibrosis. We describe a peptide-based positron emission tomography (PET) probe (⁶⁸Ga-CBP8) that targets collagen type I. We evaluated ⁶⁸Ga-CBP8 in vivo in the bleomycin-induced mouse model of pulmonary fibrosis. ⁶⁸Ga-CBP8 showed high specificity for pulmonary fibrosis and high target/background ratios in diseased animals. The lung PET signal and lung ⁶⁸Ga-CBP8 uptake (quantified ex vivo) correlated linearly (r² = 0.80) with the amount of lung collagen in mice with fibrosis. We further demon

SUBMITTER: Desogere P 

PROVIDER: S-EPMC5568793 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature