A Cooperative Mechanism Involving Ca²⁺-Permeable AMPA Receptors and Retrograde Activation of GABA_B Receptors in Interpeduncular Nucleus Plasticity.

ABSTRACT: The medial habenula-interpeduncular nucleus (MHb-IPN) pathway, which connects the limbic forebrain to the midbrain, has recently been implicated in aversive behaviors. The MHb-IPN circuit is characterized by a unique topographical organization, an excitatory role of GABA, and a prominent co-release of neurotransmitters and neuropeptides. However, little is known about synaptic plasticity in this pathway. An application of a high-frequency stimulation resulted in a long-lasting potentiation of glutamate release in IPN neurons. Our experiments reveal that a Ca²⁺-permeable AMPA receptor (CPAR)-dependent release of GABA from IPN neurons and a retrograde activation of GABA_B receptors on MHb terminals result in a long-lasting enhancement of glutamate release. Strikingly, ad

SUBMITTER: Koppensteiner P 

PROVIDER: S-EPMC5568868 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature