Ontology highlight
ABSTRACT:
SUBMITTER: Satagopan JM
PROVIDER: S-EPMC5568905 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Satagopan Jaya M JM Iasonos Alexia A
Contemporary clinical trials 20170222
Clinical and epidemiological studies of anticancer therapies increasingly seek to identify predictive biomarkers to obtain insights into variation in treatment benefit. For time to event endpoints, a predictive biomarker is typically assessed using the interaction between the biomarker and treatment in a proportional hazards model. Interactions are contrasts of summaries of outcomes and depend upon the choice of the outcome scale. In this paper, we investigate interaction contrasts under three s ...[more]