Exercise versus vasodilator stress limb perfusion imaging for the assessment of peripheral artery disease.

ABSTRACT:

Purpose

Our aim was to determine whether pharmacologic vasodilation is an alternative to exercise stress during limb perfusion imaging for peripheral artery disease (PAD).

Methods

Quantitative contrast-enhanced ultrasound (CEU) perfusion imaging of the bilateral anterior thigh and calf was performed in nine control subjects and nine patients with moderate to severe PAD at rest and during vasodilator stress with dipyridamole. For those who were able, CEU of the calf was then performed during modest plantar flexion exercise (20 watts). CEU time-intensity data were analyzed to quantify microvascular blood flow (MBF) and its parametric components of microvascular blood volume and flux rate.

Results

Thigh and calf skeletal muscle MBF at rest was similar between control and

SUBMITTER: Davidson BP 

PROVIDER: S-EPMC5568936 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature