Can we predict fall asthma exacerbations? Validation of the seasonal asthma exacerbation index.

ABSTRACT:

Background

A Seasonal Asthma Exacerbation Predictive Index (saEPI) was previously reported based on 2 prior National Institute of Allergy and Infectious Diseases Inner City Asthma Consortium trials.

Objective

This study sought to validate the saEPI in a separate trial designed to prevent fall exacerbations with omalizumab therapy.

Methods

The saEPI and its components were analyzed to characterize those who had an asthma exacerbation during the Preventative Omalizumab or Step-Up Therapy for Fall Exacerbations (PROSE) study. We characterized those inner-city children with and without asthma exacerbations in the fall period treated with guidelines-based therapy (GBT) in the absence and presence of omalizumab.

Results

A higher saEPI was associated with an exacerbat

SUBMITTER: Hoch HE 

PROVIDER: S-EPMC5568982 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature