Common and specific genes and peripheral biomarkers in children and adults with attention-deficit/hyperactivity disorder.

ABSTRACT:

Objectives

Elucidating the biological mechanisms involved in attention-deficit/hyperactivity disorder (ADHD) has been challenging. Relatively unexplored is the fact that these mechanisms can differ with age.

Methods

We present an overview on the major differences between children and adults with ADHD, describing several studies from genomics to metabolomics performed in ADHD children and in adults (cADHD and aADHD, respectively). A systematic search (up until February 2016) was conducted.

Results

From a PRISMA flow-chart, a total of 350 and 91 genomics and metabolomics studies were found to be elligible for cADHD and aADHD, respectively. For children, associations were found for genes belonging to dopaminergic (SLC6A3, DRD4 and MAOA) and neurodevelopmental (LPHN3 and

SUBMITTER: Bonvicini C 

PROVIDER: S-EPMC5568996 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature