Exploring dengue genome to construct a multi-epitope based subunit vaccine by utilizing immunoinformatics approach to battle against dengue infection.

ABSTRACT: Dengue is considered as a major health issue which causes a number of deaths worldwide each year; tropical countries are majorly affected by dengue outbreaks. It is considered as life threatening issue because, since many decades not a single effective approach for treatment and prevention of dengue has been developed. Therefore, to find new preventive measure, we used immunoinformatics approaches to develop a multi-epitope based subunit vaccine for dengue which can generate various immune responses inside the host. Different B-cell, T_C cell, and T_H cell binding epitopes were predicted for structural and non-structural proteins of dengue virus. Final vaccine constructs consisting of T_C and T_H cell epitopes and an adjuvant (β-defensin) at N-termin

SUBMITTER: Ali M 

PROVIDER: S-EPMC5569093 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature