Threonine and tyrosine kinase may serve as a prognostic biomarker for gallbladder cancer.

ABSTRACT:

Aim

To detect the expression of threonine and tyrosine kinase (TTK) in gallbladder cancer (GBC) specimens and analyze the associations between TTK expression and clinicopathological parameters and clinical prognosis.

Methods

A total of 68 patients with GBC who underwent surgical resection were enrolled in this study. The expression of TTK in GBC tissues was detected by immunohistochemistry. The assessment of TTK expression was conducted using the H-scoring system. H-score was calculated by the multiplication of the overall staining intensity with the percentage of positive cells. The expression of TTK in the cytoplasm and nucleus was scored separately to achieve respective H-score values. The correlations between TTK expression and clinicopathological parameters and clinical

SUBMITTER: Xie Y 

PROVIDER: S-EPMC5569294 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature