FTO genotype and weight status among preadolescents: Assessing the mediating effects of obesogenic appetitive traits.

ABSTRACT: Polymorphisms in the Fat Mass and Obesity Associated (FTO) gene are robustly associated with overweight and obesity among children, although the underlying mechanisms are poorly understood. We tested if appetitive traits partially mediated the association between FTO genotype and increased BMI among a sample of US preadolescents. Data were from 178 unrelated 9-10 year olds who participated in an experimental study between 2013 and 2015. Children's DNA was isolated from buccal swabs, and the rs9939609 SNP in the FTO gene was genotyped. Children's age- and sex-adjusted BMI z-scores were computed using height and weight measured at the laboratory. Parents completed the Child Eating Behavior Questionnaire that includes three validated scales of habitual appetitive traits related to drive and r

SUBMITTER: Emond JA 

PROVIDER: S-EPMC5569318 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature