Electron Microscopic Reconstruction of Functionally Identified Cells in a Neural Integrator.

ABSTRACT: Neural integrators are involved in a variety of sensorimotor and cognitive behaviors. The oculomotor system contains a simple example, a hindbrain neural circuit that takes velocity signals as inputs and temporally integrates them to control eye position. Here we investigated the structural underpinnings of temporal integration in the larval zebrafish by first identifying integrator neurons using two-photon calcium imaging and then reconstructing the same neurons through serial electron microscopic analysis. Integrator neurons were identified as those neurons with activities highly correlated with eye position during spontaneous eye movements. Three morphological classes of neurons were observed: ipsilaterally projecting neurons located medially, contralaterally projecting neurons located

SUBMITTER: Vishwanathan A 

PROVIDER: S-EPMC5569574 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature