Estimates of absolute treatment benefit for individual patients required careful modeling of statistical interactions.

ABSTRACT:

Objectives

We aimed to compare modeling approaches to estimate the individual survival benefit of treatment with either coronary artery bypass graft surgery (CABG) or percutaneous coronary intervention (PCI) for patients with complex coronary artery disease.

Study design and setting

We estimated survival with Cox regression models that included the treatment variable (CABG/PCI) interacting with either an internally developed overall prognostic index (PI) or with individual prognostic factors. We analyzed data of patients who were randomized in the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery trial (1,800 patients, 178 deaths).

Results

A negligible interaction with the PI (P = 0.51) led to 4-year survival estimates in favor of CABG

SUBMITTER: van Klaveren D 

PROVIDER: S-EPMC5569577 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature