Nivolumab Monotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer.

ABSTRACT:

Purpose

Nivolumab, a programmed death-1 (PD-1) immune checkpoint inhibitor antibody, has demonstrated improved survival over docetaxel in previously treated advanced non-small-cell lung cancer (NSCLC). First-line monotherapy with nivolumab for advanced NSCLC was evaluated in the phase I, multicohort, Checkmate 012 trial.

Methods

Fifty-two patients received nivolumab 3 mg/kg intravenously every 2 weeks until progression or unacceptable toxicity; postprogression treatment was permitted per protocol. The primary objective was to assess safety; secondary objectives included objective response rate (ORR) and 24-week progression-free survival (PFS) rate; overall survival (OS) was an exploratory end point.

Results

Any-grade treatment-related adverse events (AEs) occurred in

SUBMITTER: Gettinger S 

PROVIDER: S-EPMC5569692 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature