Low-level maternal exposure to nicotine associates with significant metabolic perturbations in second-trimester amniotic fluid.

ABSTRACT: Decades of public health research have documented that smoking in pregnancy poses significant health risks to both mother and child. More recent studies have shown that even passive maternal exposure to secondhand smoke associates with negative birth outcomes. However, the mechanisms linking exposure to outcomes have remained obscure. As a first step toward defining the metabolic consequence of low-level nicotine exposure on fetal development, we conducted an untargeted metabolomic analysis of 81 paired samples of maternal serum and amniotic fluid collected from karyotypically normal pregnancies in the second trimester. By comparing the m/z and retention times of our mass spectral features with confirmed standards, we identified cotinine, a nicotine derivative, and used the calculated coti

SUBMITTER: Fischer ST 

PROVIDER: S-EPMC5569895 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature