RegulatorTrail: a web service for the identification of key transcriptional regulators.

ABSTRACT: Transcriptional regulators such as transcription factors and chromatin modifiers play a central role in most biological processes. Alterations in their activities have been observed in many diseases, e.g. cancer. Hence, it is of utmost importance to evaluate and assess the effects of transcriptional regulators on natural and pathogenic processes. Here, we present RegulatorTrail, a web service that provides rich functionality for the identification and prioritization of key transcriptional regulators that have a strong impact on, e.g. pathological processes. RegulatorTrail offers eight methods that use regulator binding information in combination with transcriptomic or epigenomic data to infer the most influential regulators. Our web service not only provides an intuitive web interface, but

SUBMITTER: Kehl T 

PROVIDER: S-EPMC5570139 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature