ReFOLD: a server for the refinement of 3D protein models guided by accurate quality estimates.

ABSTRACT: ReFOLD is a novel hybrid refinement server with integrated high performance global and local Accuracy Self Estimates (ASEs). The server attempts to identify and to fix likely errors in user supplied 3D models of proteins via successive rounds of refinement. The server is unique in providing output for multiple alternative refined models in a way that allows users to quickly visualize the key residue locations, which are likely to have been improved. This is important, as global refinement of a full chain model may not always be possible, whereas local regions, or individual domains, can often be much improved. Thus, users may easily compare the specific regions of the alternative refined models in which they are most interested e.g. key interaction sites or domains. ReFOLD was used to gene

SUBMITTER: Shuid AN 

PROVIDER: S-EPMC5570150 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature