The pepATTRACT web server for blind, large-scale peptide-protein docking.

ABSTRACT: Peptide-protein interactions are ubiquitous in the cell and form an important part of the interactome. Computational docking methods can complement experimental characterization of these complexes, but current protocols are not applicable on the proteome scale. pepATTRACT is a novel docking protocol that is fully blind, i.e. it does not require any information about the binding site. In various stages of its development, pepATTRACT has participated in CAPRI, making successful predictions for five out of seven protein-peptide targets. Its performance is similar or better than state-of-the-art local docking protocols that do require binding site information. Here we present a novel web server that carries out the rigid-body stage of pepATTRACT. On the peptiDB benchmark, the web server genera

SUBMITTER: de Vries SJ 

PROVIDER: S-EPMC5570166 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature