Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain.

ABSTRACT:

Background

Ependymomas account for up to 10% of childhood CNS tumors and have a high rate of tumor recurrence despite gross total resection. Recently, classification into molecular ependymoma subgroups has been established, but the mechanisms underlying the aggressiveness of certain subtypes remain widely enigmatic. The aim of this study was to dissect the clinical and biological role of telomerase reactivation, a frequent mechanism of cancer cells to evade cellular senescence, in pediatric ependymoma.

Methods

We determined telomerase enzymatic activity, hTERT mRNA expression, promoter methylation, and the rs2853669 single nucleotide polymorphism located in the hTERT promoter in a well-characterized cohort of pediatric intracranial ependymomas.

Results

In posterior fo

SUBMITTER: Gojo J 

PROVIDER: S-EPMC5570194 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature