SLiMSearch: a framework for proteome-wide discovery and annotation of functional modules in intrinsically disordered regions.

ABSTRACT: The extensive intrinsically disordered regions of higher eukaryotic proteomes contain vast numbers of functional interaction modules known as short linear motifs (SLiMs). Here, we present SLiMSearch, a motif discovery tool that scans a motif consensus, representing the specificity determinants of a motif-binding domain, against a proteome to discover putative novel motif instances. SLiMSearch applies several distinct and complementary approaches exploiting the common properties of SLiMs to predict novel motifs. Consensus matches are annotated with overlapping sequence annotation, including feature information describing protein modular architecture, post-translational modification, structure, sequence variation and experimental characterisation of functional regions. Discriminatory motif a

SUBMITTER: Krystkowiak I 

PROVIDER: S-EPMC5570202 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature