SBSPKSv2: structure-based sequence analysis of polyketide synthases and non-ribosomal peptide synthetases.

ABSTRACT: Genome guided discovery of novel natural products has been a promising approach for identification of new bioactive compounds. SBSPKS web-server has been a valuable resource for analysis of polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) gene clusters. We have developed an updated version - SBSPKSv2 which is based on comprehensive analysis of sequence, structure and secondary metabolite chemical structure data from 311 experimentally characterized PKS/NRPS gene clusters with known biosynthetic products. A completely new feature of SBSPKSv2 is the inclusion of features for search in chemical space. It allows the user to compare the chemical structure of a given secondary metabolite to the chemical structures of biosynthetic intermediates and final products. For identif

SUBMITTER: Khater S 

PROVIDER: S-EPMC5570206 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature