Blocking MIR155HG/miR-155 axis inhibits mesenchymal transition in glioma.

ABSTRACT:

Background

MIR155 host gene (MIR155HG) is a long noncoding RNA that has been considered as the primary micro (mi)RNA of miR-155. MIR155HG plays an essential role in hematopoiesis, inflammation, and tumorigenesis. Our study investigated the clinical significance, biological function, mechanisms, and small-molecule inhibitors of the MIR155HG/miR-155 axis in glioma.

Methods

We analyzed the expression of the MIR155HG/miR-155 axis and the correlation with glioma grade and patient survival using 2 different glioma gene expression datasets. Biological significance was elucidated through a series of in vitro and in vivo experiments. Furthermore, we conducted a high-throughput screening for small molecules to identify a potential inhibitor of the MIR155HG/miR-155 axis.

Results

SUBMITTER: Wu X 

PROVIDER: S-EPMC5570208 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature