MCSM-NA: predicting the effects of mutations on protein-nucleic acids interactions.

ABSTRACT: Over the past two decades, several computational methods have been proposed to predict how missense mutations can affect protein structure and function, either by altering protein stability or interactions with its partners, shedding light into potential molecular mechanisms giving rise to different phenotypes. Effectively and efficiently predicting consequences of mutations on protein-nucleic acid interactions, however, remained until recently a great and unmet challenge. Here we report an updated webserver for mCSM-NA, the only scalable method we are aware of capable of quantitatively predicting the effects of mutations in protein coding regions on nucleic acid binding affinities. We have significantly enhanced the original method by including a pharmacophore modelling and information of

SUBMITTER: Pires DEV 

PROVIDER: S-EPMC5570212 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature