TraitRateProp: a web server for the detection of trait-dependent evolutionary rate shifts in sequence sites.

ABSTRACT: Understanding species adaptation at the molecular level has been a central goal of evolutionary biology and genomics research. This important task becomes increasingly relevant with the constant rise in both genotypic and phenotypic data availabilities. The TraitRateProp web server offers a unique perspective into this task by allowing the detection of associations between sequence evolution rate and whole-organism phenotypes. By analyzing sequences and phenotypes of extant species in the context of their phylogeny, it identifies sequence sites in a gene/protein whose evolutionary rate is associated with shifts in the phenotype. To this end, it considers alternative histories of whole-organism phenotypic changes, which result in the extant phenotypic states. Its joint likelihood framework

SUBMITTER: Levy Karin E 

PROVIDER: S-EPMC5570260 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature