Combinatorial effects of zinc deficiency and arsenic exposure on zebrafish (Danio rerio) development.

ABSTRACT: Zinc deficiency and chronic low level exposures to inorganic arsenic in drinking water are both significant public health concerns that affect millions of people including pregnant women. These two conditions can co-exist in the human population but little is known about their interaction, and in particular, whether zinc deficiency sensitizes individuals to arsenic exposure and toxicity, especially during critical windows of development. To address this, we utilized the Danio rerio (zebrafish) model to test the hypothesis that parental zinc deficiency sensitizes the developing embryo to low-concentration arsenic toxicity, leading to altered developmental outcomes. Adult zebrafish were fed defined zinc deficient and zinc adequate diets and were spawned resulting in zinc adequate and zinc de

SUBMITTER: Beaver LM 

PROVIDER: S-EPMC5570330 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature