HSF-1 is a regulator of miRNA expression in Caenorhabditis elegans.

ABSTRACT: The ability of an organism to sense and adapt to environmental stressors is essential for proteome maintenance and survival. The highly conserved heat shock response is a survival mechanism employed by all organisms, including the nematode Caenorhabditis elegans, upon exposure to environmental extremes. Transcriptional control of the metazoan heat shock response is mediated by the heat shock transcription factor HSF-1. In addition to regulating global stress-responsive genes to promote stress-resistance and survival, HSF-1 has recently been shown to regulate stress-independent functions in controlling development, metabolism, and longevity. However, the indirect role of HSF-1 in coordinating stress-dependent and -independent processes through post-transcriptional regulation is largely unkn

SUBMITTER: Brunquell J 

PROVIDER: S-EPMC5570370 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature