Development of a tool for prediction of ovarian cancer in patients with adnexal masses: Value of plasma fibrinogen.

ABSTRACT:

Objective

To develop a tool for individualized risk estimation of presence of cancer in women with adnexal masses, and to assess the added value of plasma fibrinogen.

Study design

We performed a retrospective analysis of a prospectively maintained database of 906 patients with adnexal masses who underwent cystectomy or oophorectomy. Uni- and multivariate logistic regression analyses including pre-operative plasma fibrinogen levels and established predictors were performed. A nomogram was generated to predict the probability of ovarian cancer. Internal validation with split-sample analysis was performed. Decision curve analysis (DCA) was then used to evaluate the clinical net benefit of the prediction model.

Results

Ovarian cancer including borderline tumours was found

SUBMITTER: Seebacher V 

PROVIDER: S-EPMC5570374 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature