Comparative study with new accuracy metrics for target volume contouring in PET image guided radiation therapy.

ABSTRACT: The impact of PET on radiation therapy is held back by poor methods of defining functional volumes of interest. Many new software tools are being proposed for contouring target volumes but the different approaches are not adequately compared and their accuracy is poorly evaluated due to the illdefinition of ground truth. This paper compares the largest cohort to date of established, emerging and proposed PET contouring methods, in terms of accuracy and variability. We emphasise spatial accuracy and present a new metric that addresses the lack of unique ground truth. 30 methods are used at 13 different institutions to contour functional VOIs in clinical PET/CT and a custom-built PET phantom representing typical problems in image guided radiotherapy. Contouring methods are grouped according

SUBMITTER: Shepherd T 

PROVIDER: S-EPMC5570440 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature