Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles.

ABSTRACT: The liver plays a pivotal role in metabolism and xenobiotic detoxification, processes that must be particularly efficient when animals are active and feed. A major question is how the liver adapts to these diurnal changes in physiology. Here, we show that, in mice, liver mass, hepatocyte size, and protein levels follow a daily rhythm, whose amplitude depends on both feeding-fasting and light-dark cycles. Correlative evidence suggests that the daily oscillation in global protein accumulation depends on a similar fluctuation in ribosome number. Whereas rRNA genes are transcribed at similar rates throughout the day, some newly synthesized rRNAs are polyadenylated and degraded in the nucleus in a robustly diurnal fashion with a phase opposite to that of ribosomal protein synthesis. Based on st

SUBMITTER: Sinturel F 

PROVIDER: S-EPMC5570523 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature