BsmI (rs1544410) and FokI (rs2228570) vitamin D receptor polymorphisms, smoking, and body mass index as risk factors of cutaneous malignant melanoma in northeast Italy.

ABSTRACT:

Objective

: To investigate whether vitamin D receptor gene (VDR) BsmI-rs1544410 and FokI-rs2228570 polymorphisms, smoking duration, and body mass index (BMI) are risk factors for cutaneous melanoma, especially metastatic melanoma.

Methods

: We studied 120 cutaneous melanoma cases [68 stage I and II non-metastatic melanoma (NMetM) patients, plus 52 Stage III and IV metastatic melanoma (MetM) patients], and 120 matching healthy controls from northeast Italy. VDR polymorphisms were measured by restriction fragment length polymorphism analysis. Absence or presence of BsmI and FokI restriction sites was denoted by " B" and " F" or by " b" and " f," respectively.

Results

: VDR-BsmI bb genotype was more frequent among MetM (32.7%) than among NMetM cases

SUBMITTER: Cauci S 

PROVIDER: S-EPMC5570607 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature