BRG1 (Brahma-Related Gene 1) Promotes Endothelial Mrtf Transcription to Establish Embryonic Capillary Integrity.

ABSTRACT:

Objective

The chromatin remodeling enzyme BRG1 (brahma-related gene 1) transcriptionally regulates target genes important for early blood vessel development and primitive hematopoiesis. However, because Brg1 deletion in vascular progenitor cells results in lethal anemia by embryonic day 10.5 (E10.5), roles for BRG1 in embryonic vascular development after midgestation are unknown. In this study, we sought to determine whether endothelial cell BRG1 regulates genes important for vascular development or maintenance later in embryonic development.

Approach and results

Using mice with temporally inducible deletion of endothelial BRG1 (Brg1^fl/fl;Cdh5(PAC)-Cre^ERT2 ), we found that Brg1 excision between E9.5 and 11.5 res

SUBMITTER: Menendez MT 

PROVIDER: S-EPMC5570645 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature