NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival.

ABSTRACT: The lifespan of neutrophils is plastic and highly responsive to factors that regulate cellular survival. Defects in neutrophil number and survival are common to both hematologic disorders and chronic inflammatory diseases. At sites of inflammation, neutrophils respond to multiple signals that activate protein kinase A (PKA) signaling, which positively regulates neutrophil survival. The aim of this study was to define transcriptional responses to PKA activation and to delineate the roles of these factors in neutrophil function and survival. In human neutrophil gene array studies, we show that PKA activation upregulates a significant number of apoptosis-related genes, the most highly regulated of these being NR4A2 and NR4A3 Direct PKA activation by the site-selective PKA agonis

SUBMITTER: Prince LR 

PROVIDER: S-EPMC5570679 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature