Dataset Information

A Strategy for Nonmigrating Highly Plasticized PVC.

ABSTRACT: Nonmigrating highly plasticized PVC was prepared based on a new compound that acts as a plasticizer that was derived from di(2-ethylhexyl) 4-hydrophthalate and chlorinated paraffin-52. The as-prepared PVC has a plasticizing efficiency as high as DOP and its migration is totally suppressed. Unlike other reported methods, this approach increases the interaction between phthalate and PVC to suppress its migration, not simply to enlarge its molecular size (or molecular weight). This methodology is highly versatile for producing the desired non-leaching PVC with a permanent plasticizer effect.

SUBMITTER: Yuan J

PROVIDER: S-EPMC5570904 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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A Strategy for Nonmigrating Highly Plasticized PVC.

Yuan Jun J Cheng Bin B

Scientific reports 20170824 1

Nonmigrating highly plasticized PVC was prepared based on a new compound that acts as a plasticizer that was derived from di(2-ethylhexyl) 4-hydrophthalate and chlorinated paraffin-52. The as-prepared PVC has a plasticizing efficiency as high as DOP and its migration is totally suppressed. Unlike other reported methods, this approach increases the interaction between phthalate and PVC to suppress its migration, not simply to enlarge its molecular size (or molecular weight). This methodology is h ...[more]

PMID: 28839284

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Project description:Medical tubings in plasticized polyvinylchloride (PVC) are widely used for the infusion of medications but are known in some cases to cause content-container interactions (drug sorption and plasticizer release). The aim of this study was to assess interactions between drugs and five alternative materials to a reference plasticized PVC intravenous (IV) infusion tubing: three were PVC coextruded with polyethylene (PE), polyurethane (PU) or a thermoplastic elastomer (Styrene-EthyleneButadiene-Styrene (SEBS)) and two were SEBS or thermoplastic olefin (TPO) monolayer tubings. Diazepam and insulin were chosen as respective reference of absorption and adsorption while paracetamol acted as a negative control. The concentration of each drug was quantified with liquid chromatography to evaluate a potential loss after a static contact condition and simulated infusion at 1 mL/h and 10 mL/h dynamic condition by an electric syringe pump. A characterization of each material's surface was performed by Fourier transform infrared spectroscopy in attenuated total reflection mode (ATR-FTIR) and by measurement of surface zeta potential. Plasticizer release was quantified by gas chromatography coupled with mass spectrometry (GC-MS). For all tubings except PVC/PU, no loss of paracetamol was observed in any condition. Diazepam sorption appeared to be less important with PVC/PE, PVC/SEBS, SEBS and TPO tubings than with PVC, but was more important when using PVC/PU tubings. PVC tubings induced the least loss of insulin amongst all the studied materials. Surface analysis by ATR-FTIR highlighted the presence of a plasticizer (that could be attributed to Tris (2-Ethylhexyl) Trimellitate (TOTM)) in the coextruded SEBS layer of PVC/SEBS, which could have influenced drug sorption, probably as a consequence of a migration from the PVC layer. Coextruded PVC/SEBS and PVC/PE presented the lowest zeta potential of all studied materials with respective values of -39 mV and -36 mV and were related to the highest sorption of insulin while PVC/PU with the highest zeta potential (about -9 mV) presented the highest absorption of diazepam. Coextruded layered materials appeared to have a lower plasticizer release than PVC alone. As a conclusion, PVC/PE and thermoplastic elastomers alone or coextruded with PVC could be interesting alternatives to PVC tubings with regards to sorption phenomena and plasticizer release.

Dataset Information

A Strategy for Nonmigrating Highly Plasticized PVC.

Publications

A Strategy for Nonmigrating Highly Plasticized PVC.

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