Genome-wide association study of bronchopulmonary dysplasia: a potential role for variants near the CRP gene.

ABSTRACT: Bronchopulmonary dysplasia (BPD), the main consequence of prematurity, has a significant heritability, but little is known about predisposing genes. The aim of this study was to identify gene loci predisposing infants to BPD. The initial genome-wide association study (GWAS) included 174 Finnish preterm infants of gestational age 24-30 weeks. Thereafter, the most promising single-nucleotide polymorphisms (SNPs) associated with BPD were genotyped in both Finnish (n = 555) and non-Finnish (n = 388) replication cohorts. Finally, plasma CRP levels from the first week of life and the risk of BPD were assessed. SNP rs11265269, flanking the CRP gene, showed the strongest signal in GWAS (odds ratio [OR] 3.2, p = 3.4 × 10^-6). This association was nominally replicated in Finnish and French

SUBMITTER: Mahlman M 

PROVIDER: S-EPMC5571168 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature