The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development.

ABSTRACT: The zebrafish kidney is conserved with other vertebrates, making it an excellent genetic model to study renal development. The kidney collects metabolic waste using a blood filter with specialized epithelial cells known as podocytes. Podocyte formation is poorly understood but relevant to many kidney diseases, as podocyte injury leads to progressive scarring and organ failure. zeppelin (zep) was isolated in a forward screen for kidney mutants and identified as a homozygous recessive lethal allele that causes reduced podocyte numbers, deficient filtration, and fluid imbalance. Interestingly, zep mutants had a larger interrenal gland, the teleostean counterpart of the mammalian adrenal gland, which suggested a fate switch with the related podocyte lineage since cell proliferation and cell de

SUBMITTER: Kroeger PT 

PROVIDER: S-EPMC5571230 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature