West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.

ABSTRACT: West Nile virus (WNV) is a mosquito-borne flavivirus that causes epidemics of encephalitis and viscerotropic disease worldwide. This virus has spread rapidly and has posed a significant public health threat since the outbreak in New York City in 1999. The interferon (IFN)-mediated antiviral response represents an important component of virus-host interactions and plays an essential role in regulating viral replication. Previous studies have suggested that multifunctional nonstructural proteins encoded by flaviviruses antagonize the host IFN response via various means in order to establish efficient viral replication. In this study, we demonstrated that the nonstructural protein 1 (NS1) of WNV antagonizes IFN-β production, most likely through suppression of retinoic acid-inducible gene I (R

SUBMITTER: Zhang HL 

PROVIDER: S-EPMC5571242 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature