Seven-CpG-based prognostic signature coupled with gene expression predicts survival of oral squamous cell carcinoma.

ABSTRACT:

Background

DNA methylation has started a recent revolution in genomics biology by identifying key biomarkers for multiple cancers, including oral squamous cell carcinoma (OSCC), the most common head and neck squamous cell carcinoma.

Methods

A multi-stage screening strategy was used to identify DNA-methylation-based signatures for OSCC prognosis. We used The Cancer Genome Atlas (TCGA) data as training set which were validated in two independent datasets from Gene Expression Omnibus (GEO). The correlation between DNA methylation and corresponding gene expression and the prognostic value of the gene expression were explored as well.

Results

The seven DNA methylation CpG sites were identified which were significantly associated with OSCC overall survival. Prognostic signa

SUBMITTER: Shen S 

PROVIDER: S-EPMC5571486 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature