Antibiotic exposure and risk of weight gain and obesity: protocol for a systematic review.

ABSTRACT:

Background

The prevalence of obesity is increasing worldwide, and there is growing interest in better delineating the role of the human gut microbiome in this phenomenon. Obesity-specific gut microbiome features have been observed in both human and animal studies, and these variations appear to play a causative role in increasing body weight. There is evidence that antibiotics can modify the composition and diversity of the gut microbiome and that this may contribute to body weight changes. The primary objective of the proposed systematic review is to evaluate and synthesize the existing evidence evaluating the possible association between antibiotic use, weight gain, and obesity.

Methods

A comprehensive search of the MEDLINE and EMBASE databases will be performed. Both rand

SUBMITTER: Dutton H 

PROVIDER: S-EPMC5571496 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature