Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care.

ABSTRACT:

Objective

To assess whether supplementation with calcium and cholecaliferol (vitamin D3) reduces the risk of fracture in women with one or more risk factors for fracture of the hip.

Design

Pragmatic open randomised controlled trial.

Setting

Practice nurse led clinics in primary care.

Participants

3314 women aged 70 and over with one or more risk factors for hip fracture: any previous fracture, low body weight (< 58 kg), smoker, family history of hip fracture, or fair or poor self reported health.

Intervention

Daily oral supplementation using 1000 mg calcium with 800 IU cholecaliferol and information leaflet on dietary calcium intake and prevention of falls, or leaflet only (control group).

Main outcome measures

Primary outcome measure was all clin

SUBMITTER: Porthouse J 

PROVIDER: S-EPMC557150 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature