Obesity and metabolic dysfunction severely influence prostate cell function: role of insulin and IGF1.

ABSTRACT: Obesity is a major health problem that courses with severe comorbidities and a drastic impairment of homeostasis and function of several organs, including the prostate gland (PG). The endocrine-metabolic regulatory axis comprising growth hormone (GH), insulin and IGF1, which is drastically altered under extreme metabolic conditions such as obesity, also plays relevant roles in the development, modulation and homeostasis of the PG. However, its implication in the pathophysiological interplay between obesity and prostate function is still to be elucidated. To explore this association, we used a high fat-diet obese mouse model, as well as in vitro primary cultures of normal-mouse PG cells and human prostate cancer cell lines. This approach revealed that most of the components of the GH/insuli

SUBMITTER: L-Lopez F 

PROVIDER: S-EPMC5571563 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature