Genetic influences on the human oral microbiome.

ABSTRACT:

Background

The human oral microbiome is formed early in development. Its composition is influenced by environmental factors including diet, substance use, oral health, and overall health and disease. The influence of human genes on the composition and stability of the oral microbiome is still poorly understood. We studied both environmental and genetic characteristics on the oral microbiome in a large twin sample as well as in a large cohort of unrelated individuals. We identify several significantly heritable features of the oral microbiome. The heritability persists in twins even when their cohabitation changes. The heritability of these traits correlates with the cumulative genetic contributions of over half a million single nucleotide sequence variants measured in a different p

SUBMITTER: Demmitt BA 

PROVIDER: S-EPMC5571580 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature