Microbial regulation of microRNA expression in the amygdala and prefrontal cortex.

ABSTRACT:

Background

There is growing evidence for a role of the gut microbiome in shaping behaviour relevant to many psychiatric and neurological disorders. Preclinical studies using germ-free (GF) animals have been essential in contributing to our current understanding of the potential importance of the host microbiome for neurodevelopment and behaviour. In particular, it has been repeatedly demonstrated that manipulation of the gut microbiome modulates anxiety-like behaviours. The neural circuits that underlie anxiety- and fear-related behaviours are complex and heavily depend on functional communication between the amygdala and prefrontal cortex (PFC). Previously, we have shown that the transcriptional networks within the amygdala and PFC of GF mice are altered. MicroRNAs (miRNAs) act th

SUBMITTER: Hoban AE 

PROVIDER: S-EPMC5571609 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature