Oxalobacter formigenes-associated host features and microbial community structures examined using the American Gut Project.

ABSTRACT:

Background

Increasing evidence shows the importance of the commensal microbe Oxalobacter formigenes in regulating host oxalate homeostasis, with effects against calcium oxalate kidney stone formation, and other oxalate-associated pathological conditions. However, limited understanding of O. formigenes in humans poses difficulties for designing targeted experiments to assess its definitive effects and sustainable interventions in clinical settings. We exploited the large-scale dataset from the American Gut Project (AGP) to study O. formigenes colonization in the human gastrointestinal (GI) tract and to explore O. formigenes-associated ecology and the underlying host-microbe relationships.

Results

In >8000 AGP samples, we detected two dominant, co-colonizing O. formigenes oper

SUBMITTER: Liu M 

PROVIDER: S-EPMC5571629 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature