Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery.

ABSTRACT: This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C₁₂ and C₁₄ tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol-yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity.

SUBMITTER: Gaitor JC 

PROVIDER: S-EPMC5571731 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature