Association of Estimated Sodium Intake With Adverse Cardiac Structure and Function: From the HyperGEN Study.

ABSTRACT:

Background

The optimal level of sodium intake remains controversial.

Objectives

This study sought to determine whether examination of left ventricular longitudinal strain (LS), circumferential strain, and e' velocity can provide insight into thresholds for the detrimental effects of estimated sodium intake (ESI) on subclinical cardiovascular disease.

Methods

We performed speckle-tracking analysis on HyperGEN (Hypertension Genetic Epidemiology Network) study echocardiograms with available urinary sodium data (N = 2,996). We evaluated the associations among ESI and LS, circumferential strain, and e' velocity using multivariable-adjusted linear mixed-effects models (to account for relatedness among subjects) with linear splines (spline 1: ESI ≤3.7 g/day, spline 2: ESI >3

SUBMITTER: Selvaraj S 

PROVIDER: S-EPMC5571737 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature