Could clinical photochemical internalisation be optimised to avoid neuronal toxicity?

ABSTRACT: Photochemical Internalisation (PCI) is a novel drug delivery technology in which low dose photodynamic therapy (PDT) can selectively rupture endo/lysosomes by light activation of membrane-incorporated photosensitisers, facilitating intracellular drug release in the treatment of cancer. For PCI to be developed further, it is important to understand whether nerve damage is an impending side effect when treating cancers within or adjacent to nervous system tissue. Dorsal root ganglion (DRG) neurons and their associated satellite glia were subjected to PCI treatment in a 3D co-culture system following incubation with photosensitisers: meso-tetraphenylporphine (TPPS_2a) or tetraphenylchlorin disulfonate (TPCS₂a) and Bleomycin. Results from the use of 3D co-culture models de

SUBMITTER: O'Rourke C 

PROVIDER: S-EPMC5571751 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature