The Chronic Kidney Disease Water Intake Trial: Protocol of a Randomized Controlled Trial.

ABSTRACT:

Background

In observational studies, drinking more water associates with a slower rate of kidney function decline; whether the same is true in a randomized controlled trial is unknown.

Objective

To examine the 1-year effect of a higher vs usual water intake on estimated glomerular filtration rate (eGFR) in patients with chronic kidney disease.

Design

Parallel-group randomized controlled trial.

Setting

Nine centers in Ontario, Canada. Enrollment and randomization occurred between May 2013 and May 2016; follow-up for the primary outcome will continue until June 2017.

Participants

Adults (n = 631) with stage 3 chronic kidney disease (eGFR 30-60 mL/min/1.73 m²) and microalbuminuria.

Intervention

The high water intake group was coached to in

SUBMITTER: Clark WF 

PROVIDER: S-EPMC5571765 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature